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Strain Number HY7207

The information provided is general academic and patent-related content concerning the raw material and does not describe the efficacy or effects of any specific product.Strain Numbers are assigned by hy in accordance with internal Strain management and naming standards, following the identification of Strain characteristics through in-house research.
Strain Information
TypeNotified probiotics
Functional
PropertiesMay help promote the growth of beneficial bacteria, inhibit harmful bacteria, support regular bowel movements, and contribute to gut health
SpeciesLactobacillus casei
StrainHY7207
OriginMakgeolli
Certifications-
Distinct Characteristics of the Strain
Strain Number HY7207
The notified probiotic Strain Number HY7207
is a beneficial microorganism that may help promote the growth of beneficial bacteria, inhibit harmful bacteria, support regular bowel movements, and contribute to gut health.The notified probiotic Strain Number HY7207
is a beneficial microorganism that may help promote the growth of beneficial bacteria, inhibit harmful bacteria, support regular bowel movements, and contribute to gut health.At hy Research Center, Strain Numbers are assigned in accordance with internal management standards, and continuous research is conducted on the various efficacies and characteristics of each Strain.At hy Research Center, Strain Numbers are assigned
in accordance with internal management standards, and continuous research is conducted on the various efficacies and characteristics of each Strain.
Research on the Strain
The hy Research Center is conducting research on the functional properties of Strain Number HY7207.Understanding Strain-specific capabilities, even within the same probiotic species, is key to hy’s mission to become a leader in microbiome science. Explore the current research on Strain Number HY7207.
Research Papers
Patents
Research Papers on Strain HY7207

[SCIE] A Study on the Efficacy of L. paracasei  HY7207 in Improving Non-Alcoholic Fatty Liver Disease (NAFLD)

Probiotics are not only beneficial for gut health but may also help suppress fat accumulation in the liver and alleviate liver inflammation and fibrosis.

 

This study investigated the effects of L. paracasei  HY7207, derived from a traditional Korean beverage, on liver health indicators in hepatocytes (HepG2) and a mouse model with induced non-alcoholic fatty liver disease (NAFLD).

 

The results demonstrated the following functional properties of HY7207:

  • Reduction of fat accumulation and the expression of lipogenesis-related genes in hepatocytes (in vitro study)
  • Improvement of hepatic steatosis (fatty liver disease) and serum biochemical markers (animal study)
  • Suppression of genes related to lipid synthesis (Srebp1c, Fasn, etc.)
  • Reduced gene expression related to liver inflammation (Tnf, Il1b, etc.) and fibrosis (Col1a1, Tgfb1, etc.)
  • Protection of liver tissue with the regulation of apoptosis-related factors

 

When administered daily (1x109 CFU/kg) for 8 weeks to an NAFLD-induced model, it demonstrated significant effectiveness in protecting liver function by reducing hepatic fat accumulation and inhibiting inflammatory and fibrotic processes.

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The information provided is general academic and patent-related content concerning the raw material and does not describe the efficacy or effects of any specific product.
Research Papers on Strain HY7207

[SCIE] A Study on Liver Function Enhancement by Probiotic Metabolites Using "Gut-Liver Axis Chip" Technology

Probiotics are not only beneficial for gut health but may also be effective in activating and protecting liver function through metabolic substances produced by gut microbiota.

 

In this study, a "gut-liver-axis chip" model was developed to replicate the connection between the intestines and liver in the human body, and the effects of probiotic-derived metabolites and exosomes on the physiological functions of a 3D liver cell culture model were analyzed.

 

The results demonstrated the following functional properties of microbial-derived metabolites and exosomes:

  • Significant improvement in protein synthesis in liver cells (increased albumin secretion)
  • Increased secretion of urea, a key marker of liver detoxification function
  • Confirmation of liver function enhancement effects of microbial signaling molecules that have crossed the intestinal barrier
  • Verification of biomimetic responses with a 3D liver cell culture model
  • Demonstration of the mechanism of complex interactions between the intestines and the liver (gut-liver axis).

 

The results of experiments using a gut-liver axis chip demonstrated that beneficial components derived from probiotics can be delivered to liver cells through the intestinal barrier to directly strengthen and support core liver functions.

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The information provided is general academic and patent-related content concerning the raw material and does not describe the efficacy or effects of any specific product.
Patents Associated with Strain HY7207
Patent Registration No. 10-1955276

Lactobacillus casei HY7207 with efficacy in improving non-alcoholic fatty liver disease (NAFLD) and products containing the same as an active ingredient

It inhibits fatty acid-induced hepatocyte apoptosis and lipid accumulation. It reduces the expression of genes involved in lipid synthesis (FAS, SREBP-1, SREBP-2, HMGCR) and has the effect of suppressing hepatic fat accumulation and body weight gain in animal models of obesity induced by a high-fat diet.

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The information provided is general academic and patent-related content concerning the raw material and does not describe the efficacy or effects of any specific product.