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Probiotics are not only beneficial for gut health but may also be effective in strengthening the physical integrity of the intestinal wall and activating immune cells to boost the body's defense system.

In this study, we analyzed the viability of B. lactis HY8002 in the gastrointestinal tract and its effects on Peyer's patch cells and intestinal barrier reinforcement.

The results demonstrated the following functional properties of HY8002:

• Strong survival and adhesion ability: Demonstrated the highest survival rate among Bifidobacterium strains in the gastrointestinal environment and excellent adhesion to intestinal epithelial cells
• Promotion of immune factor (IgA) production: Significantly increased the secretion of immunoglobulin A (IgA), which acts as the first line of defense in the gut, in both cell and animal models
• Recovery from antibiotic-induced damage: Restored the number of Peyer's cells and serum and fecal IgA levels that were reduced by antibiotic (kanamycin) treatment
• Strengthening of tight junctions: Increased the expression of proteins and genes (e.g., ZO-1) that maintain intestinal barrier integrity, preventing barrier loosening
• TLR2-mediated mechanism: Scientifically demonstrated that barrier reinforcement and immune enhancement effects are mediated through TLR2 receptors
• Microbiome restoration and safety: Restored the gut microbiota disrupted by antibiotics and confirmed the absence of toxic factors through genomic analysis

Analysis based on animal and cell experiments demonstrated that HY8002 is a potent functional probiotic that activates the intestinal immune system and strengthens physical barriers to protect the body from harmful external factors.

Probiotics are not only beneficial for gut health but may also be effective in alleviating lung inflammation caused by the inhalation of fine dust and boosting respiratory defenses

This study examined the changes in lung inflammation markers and antioxidant responses when L. casei HY2782 and B. lactis HY8002 were orally administered to a mouse model chronically exposed to particulate matter (PM2.5).

The results demonstrated the following functional properties of HY2782 and HY8002:

• Inhibition of inflammatory cell infiltration: Effectively prevented the infiltration of eosinophils and neutrophils that exacerbate inflammation in bronchoalveolar lavage fluid (BALF)
• Inhibition of leukocyte activation and inflammatory cytokines: Reduced the migration of leukocytes activated by fine dust and alleviated the production of inflammation-inducing substances
• Increased antioxidant enzyme activity: Reduced oxidative stress by increasing the activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase in the blood
• Removal of reactive oxygen species (ROS): Effectively eliminated ROS induced by fine dust to protect cells from damage
• Confirmation of respiratory protection mechanism: Suppressed lung inflammatory responses through multiple pathways, thereby protecting respiratory health

Analysis using animal models demonstrated that HY2782 and HY8002 probiotics can act as powerful protective agents against lung damage and inflammation caused by fine dust exposure.

Probiotics are not only beneficial for gut health but may also help activate immune cells and restore compromised immune function caused by medications or other factors.

In this study, we analyzed the synergistic effects of the B. lactis  HY8002와 L. plantarum  HY7717 complex on immune markers in a mouse model with immunosuppression induced by cyclophosphamide (CTX).

The results demonstrated the following functional properties of the HY8002 and HY7717 complex:

• Increase in immune-activating cytokines: Significantly promoted the secretion of interferon gamma (IFN-γ), interleukin-12 (IL-12), and tumor necrosis factor (TNF-α), which play key roles in immune responses, from splenocytes
• Improvement in blood and immune indicators: Effectively restored spleen indices and hematological values that had decreased due to immunosuppressants
• Activation of NK cells and immunoglobulins: Increased the activity of natural killer (NK) cells that target foreign invaders and increased plasma immunoglobulin levels, thereby strengthening the immune system
• Immunomodulation via the TLR2 pathway: Scientifically demonstrated that these immune-enhancing effects are closely associated with the activation of the immune signaling receptor TLR2
• Potential for various applications: Demonstrated high value as a functional probiotic material for boosting the immune system when applied to dairy products such as yogurt and cheese

Analysis based on animal and cell experiments demonstrated that the HY8002 and HY7717 complex can serve as an effective immune support dietary supplement by potently stimulating and restoring the body's immune response even in immunosuppressive conditions, thereby helping to protect overall health.

This is a composition that combines HY8002 with Lactobacillus plantarum HY7712 and Lactobacillus casei HY2782 to restore the disrupted intestinal flora of cancer patients or post-operative patients.

This is a composition that contains a mixture of probiotics including HY8002, HY7712, and HY2782 and natural ingredients such as lactulose, burdock, and digestion-resistant maltodextrin to improve colon function.

HY8002 is included in the list of target strains to which selenium-based probiotic coating technology can be applied.

It alleviates nicotine withdrawal symptoms by reducing the expression of nicotinic acetylcholine receptors (acr-15 and acr-19) in a Caenorhabditis elegans model.

HY8002 reduces the expression of aryl hydrocarbon receptor (AhR), CYP1A1, and CYP1B1, which increase in human skin cells exposed to fine dust. This has the effect of protecting against skin cell death induced by fine dust and prevent skin damage.

HY8002 suppresses neuronal cell death caused by stress hormones (cortisol) and oxidative stress. Specifically, it increases the expression of brain-derived neurotrophic factor (BDNF) and the cell survival factor (RELA) while decreasing the expression of the apoptotic marker caspase-3, which suggests its potential utility in the prevention and treatment of cognitive impairments, including dementia and Alzheimer’s disease, as well as depression.

Red ginseng concentrate enriched with ginsenoside Rd through mixed fermentation with HY8002 and HY8502 strains has been shown to help improve allergic rhinitis by inhibiting the production of IL-4, IL-5, and IgE and by regulating gut microbiota balance.

This technology relates to a manufacturing method for increasing the ginsenoside Rd content by fermenting red ginseng concentrate with a mixture of HY8002 and HY8502 strains in a 1:2 ratio.

This technology relates to a fermented red ginseng concentrate in which red ginseng extract is subjected to triple ethanol extraction and subsequently fermented with HY8002 and HY8502 strains, thereby increasing the absorption of active ingredients and improving the blood concentration maintenance time.

When used in combination with Platycladus orientalis leaf extract, it increases the enzyme (CYP2A6) that converts nicotine to cotinine and decreases the apoptosis factor (caspase-3), thereby alleviating nicotine toxicity and promoting breakdown

It alleviates nicotine withdrawal symptoms by reducing the expression of nicotinic acetylcholine receptors (acr-15 and acr-19) in a Caenorhabditis elegans model.