[KCI] Effects of Lactobacillus acidophilus HY7032 and Lactobacillus reuteri HY7506 isolated from dog feces on welfare and hair in companion dogs
To optimize probiotic efficacy, it is necessary to go beyond general nutritional considerations and focus on host specificity to ensure that microbial strains are biologically compatible with the unique gut environment of the target species.
In this study, we analyzed the effects of L. acidophilus HY7032 and L. reuteri HY7506, canine-derived probiotics isolated from the feces of healthy dogs, on immune cell activation, gut microbiome restoration, and coat condition improvement in dogs.
The results demonstrated the following functional properties of the canine-derived complex probiotics (HY7032 + HY7506):
- Excellent viability and antimicrobial activity: Exhibited high tolerance to gastric acid and bile acids upon ingestion and effectively suppressed harmful intestinal bacteria (basic verification)
- Enhancement of innate immune responses: Significantly promoted oxidative burst and phagocytosis, key defense mechanisms of innate immune cells in peripheral blood (cellular verification) Restoration of gut microbial dysbiosis: Progressively restored microbial balance and normalized stool patterns following 3 weeks of administration in a model where the gut microbiome had been disrupted by 7 days of potent antibiotics (vancomycin and polymyxin B) (animal study)
- Improvement of coat condition: Oral administration of the probiotic complex improved overall canine well-being as well as coat quality compared to the placebo group (animal study).
Analyses based on immune cell and Beagle dog animal models demonstrated that the HY7032 and HY7506 probiotic complex is an excellent host-specific probiotic agent for improving canine health and coat condition by suppressing harmful bacteria and restoring intestinal functions disrupted by antibiotic exposure.


