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R&D

Pioneering a sustainable future through continuous innovation from functional probiotics to natural solutions and pet care.

Pioneering a sustainable future through continuous innovation from
functional probiotics to natural solutions and pet care.

Pioneering a sustainable future through continuous innovation from functional probiotics to natural solutions and pet care.

Natural Ingredients

By combining the limitless potential of nature with hy’s technological expertise, we create greater value.

By combining the limitless potential of nature with hy’s technological expertise,
we create greater value.

By combining the limitless potential of nature with hy’s technological expertise, we create greater value.

Gastro health: Mulberry Leaf Extract Individually Approved Functional Ingredient

  • Individually
    approved
    ingredient
    No. 2021-16
    Individually
    approved
    ingredient
    No. 2021-16
  • Improvement of stomach discomfort
  • Inhibition of gastric acid secretion
    Protection of the gastric mucosa
    The above functional claims are based on animal study results.
    The above functional claims are based on animal study results.
  • Clinically Proven Ingredient
Ingredient Information
Key Ingredients
  • Mulberry leaf extract
    (Cudrania tricuspidata)
    Mulberry leaf extract (Cudrania tricuspidata)
    Mulberry leaf extract
    (Cudrania tricuspidata)
Functional benefits
  • Relieves stomach discomfort
Daily intake
  • 100 mg
Ingredient Strength
  • Low daily dosage
  • Easily incorporated into various formulations
  • Clear mechanism of action
Research Papers
  • Decrease in total stomach acid and protection against gastric mucosal injury demonstrated in in vitro and in vivo studies
  • Suppression of stomach acid secretion, enhancement of mucin production, and gastric mucosal protection demonstrated in in vitro and in vivo studies
    Suppression of stomach acid secretion, enhancement of mucin production, and gastric mucosal protection demonstrated in in vitro and in vivo studies
    Suppression of stomach acid secretion, enhancement of mucin production, and gastric mucosal protection demonstrated in in vitro and in vivo studies
  • Alleviation of symptoms including upper abdominal pain, heartburn, acid reflux, and quality of life demonstrated in the clinical trial
    Alleviation of symptoms including upper abdominal pain, heartburn, acid reflux, and quality of life demonstrated in the clinical trial
    Alleviation of symptoms including upper abdominal pain, heartburn, acid reflux, and quality of life demonstrated in the clinical trial
Patents
  • Prevention of functional dyspepsia
  • Prevention of reflux esophagitis
  • Prevention of Helicobacter pylori infection
Results of human clinical trial
Clinical Trial Design
  • One hundred adults experiencing gastrointestinal symptoms consumed 100 mg/day of Cudrania tricuspidata leaf extract for 8 weeks.
    One hundred adults experiencing gastrointestinal symptoms consumed 100 mg/day of Cudrania tricuspidata leaf extract for 8 weeks.
    One hundred adults experiencing gastrointestinal symptoms consumed 100 mg/day of Cudrania tricuspidata leaf extract for 8 weeks.
GSRS upper abdominal symptoms
  • Significant improvement was observed in eight indicators related to upper abdominal symptoms caused by acid reflux.
  • Abdominal pain
  • Heartburn
  • Acid reflux
  • Burning sensation in the abdomen
  • Nausea and vomiting
  • Abdominal rumbling
  • Abdominal bloating
  • Belching
GSRS (Gastrointestinal Symptom Rating Scale): A self-reported scale for assessing gastrointestinal symptoms such as heartburn and acid reflux.
GSRS (Gastrointestinal Symptom Rating Scale): A self-reported scale for assessing gastrointestinal symptoms such as heartburn and acid reflux.
GSRS (Gastrointestinal Symptom Rating Scale): A self-reported scale for assessing gastrointestinal symptoms such as heartburn and acid reflux.
NDI-K upper abdominal gastrointestinal symptoms
  • Significant improvement was observed in indicators related to functional dyspepsia symptoms.
    Significant improvement was observed in indicators related to functional dyspepsia symptoms.
    Significant improvement was observed in indicators related to functional dyspepsia symptoms.
    NDI-K (Nepean Dyspepsia Index): A quality of life assessment tool related to functional dyspepsia, including indicators such as upper abdominal pain and discomfort. Lower total scores indicate milder symptoms.
    NDI-K (Nepean Dyspepsia Index): A quality of life assessment tool related to functional dyspepsia, including indicators such as upper abdominal pain and discomfort. Lower total scores indicate milder symptoms.
    NDI-K (Nepean Dyspepsia Index): A quality of life assessment tool related to functional dyspepsia, including indicators such as upper abdominal pain and discomfort. Lower total scores indicate milder symptoms.
Gastroprotective effect
  • Reduces the volume and acidity of gastric juice and protects the gastric mucosa, leading to improvement in clinical symptoms such as heartburn, acid reflux, and upper abdominal pain.
    Reduces the volume and acidity of gastric juice and protects the gastric mucosa, leading to improvement in clinical symptoms such as heartburn, acid reflux, and upper abdominal pain.
    Reduces the volume and acidity of gastric juice and protects the gastric mucosa, leading to improvement in clinical symptoms such as heartburn, acid reflux, and upper abdominal pain.