R&D

Pioneering a sustainable future through continuous innovation from functional probiotics to natural solutions and pet care.

Pioneering a sustainable future through continuous innovation from
functional probiotics to natural solutions and pet care.

Pioneering a sustainable future through continuous innovation from functional probiotics to natural solutions and pet care.

hy R&D Center

With world-class research and technology, we set new standards in healthcare and contribute to healthier lives for all.
With world-class research and technology, we set new standards in healthcare and contribute to healthier lives for all.
With world-class research and technology, we set new standards in healthcare and contribute to healthier lives for all.

Achievements

  • Microbiome
    13
  • Strain Library
    5096
  • Natural Products Library
    251
  • Individually Approved Functional Ingredients
    7
  • US FDA
    s-GRAS/NDI Status strains
    4
  • Patents
    124
  • Scientific Publications
    150
Microbiome
With its strain library database, hy is conducting in-depth microbiome research.
The Microbiome: An Ecosystem Within the Human BodyThe Microbiome: An Ecosystem Within the Human Body
The microbiome refers to the community of microorganisms (microbiota)
living in the body and their genetic material (genome).
Over 95% reside in the digestive tract,
with others on the skin, respiratory system, and oral cavity,
all crucial for health and immunity.

An adult carries about 3.8 trillion
microbiome organisms, approximately 1.3 times
the number of human somatic cells.
The microbiome refers to the community of microorganisms (microbiota)
living in the body and their genetic material (genome).
Over 95% reside in the digestive tract,
with others on the skin, respiratory system, and oral cavity, all crucial for health and immunity.

An adult carries about 3.8 trillion
microbiome organisms, approximately 1.3 times
the number of human somatic cells.
The microbiome refers to the community of microorganisms (microbiota) living in the body and their genetic material (genome).
Over 95% reside in the digestive tract, with others on the skin, respiratory system, and oral cavity, all crucial for health and immunity.

An adult carries about 3.8 trillion
microbiome organisms, approximately 1.3 times the number of human somatic cells.
Key Research Outcomes
  • [Clinical Trial] Lee, et al., "Intake of MPRO3 over 4 weeks reduces glucose levels and improves gastrointestinal health and metabolism." Microorganisms 10.1 (2021): 88.
    [Clinical Trial] Lee, et al., "Association between altered blood parameters and gut microbiota after synbiotic intake in healthy, elderly Korean women." Nutrients 12.10 (2020): 3112.
    [Clinical Trial] Park, et al., "Effects of probiotics on the symptoms and surgical outcomes after anterior resection of colon cancer (POSTCARE): A randomized, double-blind, placebo-controlled trial." Journal of clinical medicine 9.7 (2020): 2181.
  • [Clinical Trial] Mo, et al., "Effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on overweight and the gut microbiota in humans: Randomized, double-blinded, placebo-controlled clinical trial." Nutrients 14.12 (2022): 2484.

    [Clinical Trial] Jung, et al., "Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects." Journal of Functional Foods 19 (2015): 744–752.

    [Clinical Trial] Kim, et al., "Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals." Food & Function 8.1 (2017): 250–261.
    [Clinical Trial] Ahn, et al., "Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduces fasting triglycerides and enhances apolipoprotein A-V levels in non-diabetic subjects with hypertriglyceridemia." Atherosclerosis 241.2 (2015): 649–656.

    [Clinical Trial] Ahn, et al., "The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects." Nutrition, Metabolism and Cardiovascular Diseases 25.8 (2015): 724–733.
  • [Clinical Trial] Lee, et al., "Clinical evidence of effects of Lactobacillus plantarum HY7714 on skin aging: A randomized, double-blind, placebo-controlled study." Journal of Microbiology and Biotechnology 25.12 (2015): 2160–2168.

    [Clinical Trial] Nam, et al., "Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition." PLoS One 15.4 (2020): e0231268.
  • [Clinical Trial] Jeon, et al., "The effects of Lilium lancifolium Thunb. on the alleviation of joint pain: A randomized, double-blind, placebo-controlled clinical trial." Life 14.9 (2024): 1136.
    [Clinical Trial] Jung, et al., "Effects of plant-based extract mixture on alcohol metabolism and hangover improvement in humans: A randomized, double-blind, paralleled, placebo-controlled clinical trial." Journal of Clinical Medicine 12.16 (2023): 5244.
    [Clinical Trial] Shin, et al., "Efficacy and safety of the Cudrania tricuspidata extract on functional dyspepsia: a randomized double-blind placebo-controlled multicenter study." Journal of clinical medicine 10.22 (2021): 5323.
    [Clinical Trial] Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng (Journal of Ginseng Research, 2020)
    [Clinical Trial] Choi, et al., "Enhanced absorption study of ginsenoside compound K (20‐O‐β‐(D‐glucopyranosyl)‐20(S)‐protopanaxadiol) after oral administration of fermented red ginseng extract (HYFRG™) in healthy Korean volunteers and rats." Evidence-Based Complementary and Alternative Medicine 2016.1 (2016): 3908142.
  • [Clinical Trial] Lee, et al., "The effect of organic vegetable mixed juice on blood circulation and intestine flora: Randomized, double-blinded, placebo-controlled clinical trial." Diseases 12.9 (2024): 223.
Strain & Natural Products Library
For over half a century, we've explored strains in various ways, looking to natural solutions around us for future possibilities. Each discovery, guided by scientific insight, is carefully analyzed and transformed into functional ingredients that enrich daily life.
For over half a century, we've explored strains in various ways, looking to natural solutions around us for future possibilities. Each discovery, guided by scientific insight, is carefully analyzed and transformed into functional ingredients that enrich daily life.
For over half a century, we've explored strains in various ways, looking to natural solutions around us for future possibilities. Each discovery, guided by scientific insight, is carefully analyzed and transformed into functional ingredients that enrich daily life.
  • Strain Library
    More than 5,096 strains
  • Natural Products Library
    251 varieties
Individually Approved Functional Ingredients
Individually Approved Ingredients by the Ministry of Food and Drug Safety
  • FatSlim™
    (Probiotics Blend of
    L. curvatus HY7601 and
    L. plantarum KY1032)
    FatSlim™
    (Probiotics Blend of
    L. curvatus HY7601
    and L. plantarum
    KY1032)
    Body Fat Loss (2019)
  • SkinCare™
    (L. plantarum HY7714)
    SkinCare™
    (L. plantarum HY7714)
    Skin hydration / Protection against
    UV-induced skin damage (2015)
  • Mulberry leaf extract
    Relief of upper respiratory discomfort (2021)
  • Tiger Lily Bulb Extract
    May help support joint health (2023)
  • Ashwagandha extract
    Relief of tension caused by stress (2012)
  • Fingerroot extract powder
    Protection against UV-induced skin damage (2012)
  • Lactic acid bacteria–fermented kelp extract
    Lactic acid bacteria–fermented kelp extract
    Protection against alcohol-induced liver damage (2011)
    Protection against alcohol-induced liver damage (2011)
US FDA-acknowledged Strains
  • L. curvatus HY7601
    L. plantarum KY1032
    L. curvatus HY7601
    L. plantarum KY1032
    L. curvatus HY7601
    L. plantarum KY1032
  • L. plantarum HY7714
    L. plantarum HY7714
    L. plantarum HY7714
  • L. paracasei HY2782
    L. paracasei HY2782
    L. paracasei HY2782
Patents & Research Papers
We provide scientific evidence through various patents and SCI-indexed publications, establishing leadership in both domestic and global healthcare markets.
Registered Patents
SCI-Level Research Papers
Research Pipeline
We are continuously exploring new possibilities to enhance human health through ongoing research.