hy R&D

Key Research Outcomes

• Probiotics for Gut Health

  [Clinical Trial] Lee, et al., "Intake of MPRO3 over 4 weeks reduces glucose levels and improves gastrointestinal health and metabolism." Microorganisms 10.1 (2021): 88.

  [Clinical Trial] Lee, et al., "Association between altered blood parameters and gut microbiota after synbiotic intake in healthy, elderly Korean women." Nutrients 12.10 (2020): 3112.

  [Clinical Trial] Park, et al., "Effects of probiotics on the symptoms and surgical outcomes after anterior resection of colon cancer (POSTCARE): A randomized, double-blind, placebo-controlled trial." Journal of clinical medicine 9.7 (2020): 2181.
• FatSlim™ Probiotics (Body Fat Loss)

  [Clinical Trial] Mo, et al., "Effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on overweight and the gut microbiota in humans: Randomized, double-blinded, placebo-controlled clinical trial." Nutrients 14.12 (2022): 2484.
  
  [Clinical Trial] Jung, et al., "Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects." Journal of Functional Foods 19 (2015): 744–752.
  
  [Clinical Trial] Kim, et al., "Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals." Food & Function 8.1 (2017): 250–261.

  [Clinical Trial] Ahn, et al., "Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduces fasting triglycerides and enhances apolipoprotein A-V levels in non-diabetic subjects with hypertriglyceridemia." Atherosclerosis 241.2 (2015): 649–656.
  
  [Clinical Trial] Ahn, et al., "The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects." Nutrition, Metabolism and Cardiovascular Diseases 25.8 (2015): 724–733.
• SkinCare™ Probiotic (Skin Moisturization and Anti-Wrinkle)

  [Clinical Trial] Lee, et al., "Clinical evidence of effects of Lactobacillus plantarum HY7714 on skin aging: A randomized, double-blind, placebo-controlled study." Journal of Microbiology and Biotechnology 25.12 (2015): 2160–2168.
  
  [Clinical Trial] Nam, et al., "Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition." PLoS One 15.4 (2020): e0231268.
• Natural Products

  [Clinical Trial] Jeon, et al., "The effects of Lilium lancifolium Thunb. on the alleviation of joint pain: A randomized, double-blind, placebo-controlled clinical trial." Life 14.9 (2024): 1136.

  [Clinical Trial] Jung, et al., "Effects of plant-based extract mixture on alcohol metabolism and hangover improvement in humans: A randomized, double-blind, paralleled, placebo-controlled clinical trial." Journal of Clinical Medicine 12.16 (2023): 5244.

  [Clinical Trial] Shin, et al., "Efficacy and safety of the Cudrania tricuspidata extract on functional dyspepsia: a randomized double-blind placebo-controlled multicenter study." Journal of clinical medicine 10.22 (2021): 5323.

  [Clinical Trial] Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng (Journal of Ginseng Research, 2020)

  [Clinical Trial] Choi, et al., "Enhanced absorption study of ginsenoside compound K (20‐O‐β‐(D‐glucopyranosyl)‐20(S)‐protopanaxadiol) after oral administration of fermented red ginseng extract (HYFRG™) in healthy Korean volunteers and rats." Evidence-Based Complementary and Alternative Medicine 2016.1 (2016): 3908142.
• Haru Yachae

  [Clinical Trial] Lee, et al., "The effect of organic vegetable mixed juice on blood circulation and intestine flora: Randomized, double-blinded, placebo-controlled clinical trial." Diseases 12.9 (2024): 223.